Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1

Metastatic tumors can prepare a distant site for colonization via the secretion of factors that act in a systemic manner. We hypothesized that non- or weakly metastatic human tumor cells may act in an opposite fashion by creating a microenvironment in distant tissues that is refractory to colonizati...

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Main Authors: Kang, Soo-Young, Halvorsen, Ole J., Gravdal, Karsten, Bhattacharya, Nandita, Lee, Jung Min, Liu, Nathan W., Johnston, Brian T., Johnston, Adam B., Haukaas, Svein A., Aamodt, Kristie, Yoo, Sun, Akslen, Lars A., Watnick, Randolph S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2009
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715504/
https://ncbi.nlm.nih.gov/pubmed/19581582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903120106
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