Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1

Metastatic tumors can prepare a distant site for colonization via the secretion of factors that act in a systemic manner. We hypothesized that non- or weakly metastatic human tumor cells may act in an opposite fashion by creating a microenvironment in distant tissues that is refractory to colonizati...

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Bibliographische Detailangaben
Hauptverfasser: Kang, Soo-Young, Halvorsen, Ole J., Gravdal, Karsten, Bhattacharya, Nandita, Lee, Jung Min, Liu, Nathan W., Johnston, Brian T., Johnston, Adam B., Haukaas, Svein A., Aamodt, Kristie, Yoo, Sun, Akslen, Lars A., Watnick, Randolph S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715504/
https://ncbi.nlm.nih.gov/pubmed/19581582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903120106
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