Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1

Metastatic tumors can prepare a distant site for colonization via the secretion of factors that act in a systemic manner. We hypothesized that non- or weakly metastatic human tumor cells may act in an opposite fashion by creating a microenvironment in distant tissues that is refractory to colonizati...

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Bibliografiske detaljer
Main Authors: Kang, Soo-Young, Halvorsen, Ole J., Gravdal, Karsten, Bhattacharya, Nandita, Lee, Jung Min, Liu, Nathan W., Johnston, Brian T., Johnston, Adam B., Haukaas, Svein A., Aamodt, Kristie, Yoo, Sun, Akslen, Lars A., Watnick, Randolph S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715504/
https://ncbi.nlm.nih.gov/pubmed/19581582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903120106
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