Addition of DNA to Cr(VI) and Cytochrome b(5) Containing Proteoliposomes Leads to Generation of DNA Strand Breaks and Cr(III) Complexes

Chromium (Cr) is a cytotoxic metal that can be associated with a variety of types of DNA damage, including Cr-DNA adducts and strand breaks. Prior studies with purified human cytochrome b(5) and NADPH :P450 reductase in reconstituted proteoliposomes (PLs) demonstrated rapid reduction of Cr(VI) (hexa...

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Hlavní autoři: Borthiry, Griselda R., Antholine, William E., Myers, Judith M., Myers, Charles R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715337/
https://ncbi.nlm.nih.gov/pubmed/18729091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbdv.200890143
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