Rapid DNA double-strand breaks resulting from processing of Cr-DNA crosslinks by both MutS dimers

Mismatch repair (MMR) strongly enhances cyto- and genotoxicity of several chemotherapeutic agents and environmental carcinogens. DNA-double-strand breaks (DSB) formed after two replication cycles play a major role in MMR-dependent cell death by DNA alkylating drugs. Here we examined DNA damage detec...

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Autori principali: Reynolds, Mindy F., Peterson-Roth, Elizabeth C., Bespalov, Ivan A., Johnston, Tatiana, Gurel, Volkan M., Menard, Haley L., Zhitkovich, Anatoly
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226787/
https://ncbi.nlm.nih.gov/pubmed/19141647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2306
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