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Addition of DNA to Cr(VI) and Cytochrome b(5) Containing Proteoliposomes Leads to Generation of DNA Strand Breaks and Cr(III) Complexes
Chromium (Cr) is a cytotoxic metal that can be associated with a variety of types of DNA damage, including Cr-DNA adducts and strand breaks. Prior studies with purified human cytochrome b(5) and NADPH :P450 reductase in reconstituted proteoliposomes (PLs) demonstrated rapid reduction of Cr(VI) (hexa...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2715337/ https://ncbi.nlm.nih.gov/pubmed/18729091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbdv.200890143 |
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