Regulation of Interleukin-5–Induced β(2)-Integrin Adhesion of Human Eosinophils by Phosphoinositide 3-Kinase

We examined the role of phosphoinositide 3-kinase (PI3K) in integrin-mediated eosinophil adhesion. Δp85, a dominant-negative form of the class IA PI3K adaptor subunit, was fused to an HIV-TAT protein transduction domain (TAT-Δp85). Recombinant TAT-Δp85 inhibited interleukin (IL)-5–stimulated phospho...

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Autors principals: Sano, Masaaki, Leff, Alan R., Myou, Shigeharu, Boetticher, Evan, Meliton, Angelo Y., Learoyd, Jonathan, Lambertino, Anissa T., Munoz, Nilda M., Zhu, Xiangdong
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2005
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715304/
https://ncbi.nlm.nih.gov/pubmed/15802551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2005-0076OC
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