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Blockade of Inflammation and Airway Hyperresponsiveness in Immune-sensitized Mice by Dominant-Negative Phosphoinositide 3-Kinase–TAT

Phosphoinositide 3-kinase (PI3K) is thought to contribute to the pathogenesis of asthma by effecting the recruitment, activation, and apoptosis of inflammatory cells. We examined the role of class IA PI3K in antigen-induced airway inflammation and hyperresponsiveness by i.p. administration into mice...

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Main Authors: Myou, Shigeharu, Leff, Alan R., Myo, Saori, Boetticher, Evan, Tong, Jiankun, Meliton, Angelo Y., Liu, Jie, Munoz, Nilda M., Zhu, Xiangdong
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2003
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194122/
https://ncbi.nlm.nih.gov/pubmed/14623911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030298
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