Blockade of Inflammation and Airway Hyperresponsiveness in Immune-sensitized Mice by Dominant-Negative Phosphoinositide 3-Kinase–TAT

Phosphoinositide 3-kinase (PI3K) is thought to contribute to the pathogenesis of asthma by effecting the recruitment, activation, and apoptosis of inflammatory cells. We examined the role of class IA PI3K in antigen-induced airway inflammation and hyperresponsiveness by i.p. administration into mice...

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Autores principales: Myou, Shigeharu, Leff, Alan R., Myo, Saori, Boetticher, Evan, Tong, Jiankun, Meliton, Angelo Y., Liu, Jie, Munoz, Nilda M., Zhu, Xiangdong
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2003
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194122/
https://ncbi.nlm.nih.gov/pubmed/14623911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030298
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