TAT-Protein Blockade during Ischemia/Reperfusion Reveals Critical Role for p85 PI3K-PTEN Interaction in Cardiomyocyte Injury

Recent work shows that cooling protection after mouse cardiac arrest and cardiomyocyte ischemia is mediated by Akt activation. The PI3K p85 subunit can either augment or inhibit Akt activation depending on its binding to p110 or PTEN respectively. To further clarify the role of PI3K p85 in cardiopro...

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Autores principales: Zhu, Xiangdong, Shao, Zuo-Hui, Li, Changqing, Li, Jing, Zhong, Qiang, Learoyd, Jonathan, Meliton, Angelo, Meliton, Lucille, Leff, Alan R., Vanden Hoek, Terry L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3994094/
https://ncbi.nlm.nih.gov/pubmed/24752319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095622
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