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TAT-Protein Blockade during Ischemia/Reperfusion Reveals Critical Role for p85 PI3K-PTEN Interaction in Cardiomyocyte Injury

Recent work shows that cooling protection after mouse cardiac arrest and cardiomyocyte ischemia is mediated by Akt activation. The PI3K p85 subunit can either augment or inhibit Akt activation depending on its binding to p110 or PTEN respectively. To further clarify the role of PI3K p85 in cardiopro...

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Detalhes bibliográficos
Main Authors: Zhu, Xiangdong, Shao, Zuo-Hui, Li, Changqing, Li, Jing, Zhong, Qiang, Learoyd, Jonathan, Meliton, Angelo, Meliton, Lucille, Leff, Alan R., Vanden Hoek, Terry L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3994094/
https://ncbi.nlm.nih.gov/pubmed/24752319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095622
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