TAT delivery of a PTEN peptide inhibitor has direct cardioprotective effects and improves outcomes in rodent models of cardiac arrest

We have recently shown that pharmacologic inhibition of PTEN significantly increases cardiac arrest survival in a mouse model, however, this protection required pretreatment 30 min before the arrest. To improve the onset of PTEN inhibition during cardiac arrest treatment, we have designed a TAT fuse...

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Détails bibliographiques
Publié dans:Am J Physiol Heart Circ Physiol
Auteurs principaux: Zhu, Xiangdong, Li, Jing, Wang, Huashan, Gasior, Filip M., Lee, Chunpei, Lin, Shaoxia, Zhu, Zhiyi, Wang, Youhua, Justice, Cody N., O'Donnell, J. Michael, Vanden Hoek, Terry L.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163648/
https://ncbi.nlm.nih.gov/pubmed/33834871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00513.2020
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