Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A

Precise control of the timing and magnitude of Notch signaling is essential for the normal development of many tissues, but the feedback loops that regulate Notch are poorly understood. Developing T cells provide an excellent context to address this issue. Notch1 signals initiate T-cell development...

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Autors principals: Yashiro-Ohtani, Yumi, He, Yiping, Ohtani, Takuya, Jones, Mary E., Shestova, Olga, Xu, Lanwei, Fang, Terry C., Chiang, Mark Y., Intlekofer, Andrew M., Blacklow, Stephen C., Zhuang, Yuan, Pear, Warren S.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2009
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714710/
https://ncbi.nlm.nih.gov/pubmed/19605688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1793709
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