Endothelial deletion of hypoxia-inducible factor–2α (HIF-2α) alters vascular function and tumor angiogenesis

Hypoxia-inducible factor–2α (HIF-2α) is highly expressed in embryonic vascular endothelial cells (ECs) and activates the expression of target genes whose products modulate vascular function and angiogenesis. In this report, we describe a genetic model designed to test the physiologic consequences of...

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Bibliographic Details
Main Authors: Skuli, Nicolas, Liu, Liping, Runge, Anja, Wang, Tao, Yuan, Lijun, Patel, Sunny, Iruela-Arispe, Luisa, Simon, M. Celeste, Keith, Brian
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2009
Subjects:
Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714217/
https://ncbi.nlm.nih.gov/pubmed/19439736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-12-193581
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