New Antibiotic Molecules: Bypassing the Membrane Barrier of Gram Negative Bacteria Increases the Activity of Peptide Deformylase Inhibitors

BACKGROUND: Multi-drug resistant (MDR) bacteria have become a major concern in hospitals worldwide and urgently require the development of new antibacterial molecules. Peptide deformylase is an intracellular target now well-recognized for the design of new antibiotics. The bacterial susceptibility t...

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Hauptverfasser: Mamelli, Laurent, Petit, Sylvain, Chevalier, Jacqueline, Giglione, Carmela, Lieutaud, Aurélie, Meinnel, Thierry, Artaud, Isabelle, Pagès, Jean-Marie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713832/
https://ncbi.nlm.nih.gov/pubmed/19649280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006443
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