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Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms

The N-terminal protein processing pathway is an essential mechanism found in all organisms. However, it is widely believed that deformylase, a key enzyme involved in this process in bacteria, does not exist in eukaryotes, thus making it a target for antibacterial agents such as actinonin. In an atte...

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Autori principali: Giglione, Carmela, Serero, Alexandre, Pierre, Michèle, Boisson, Bertrand, Meinnel, Thierry
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC305796/
https://ncbi.nlm.nih.gov/pubmed/11060042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.21.5916
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