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Trapping Conformational States Along Ligand-Binding Dynamics of Peptide Deformylase: The Impact of Induced Fit on Enzyme Catalysis

For several decades, molecular recognition has been considered one of the most fundamental processes in biochemistry. For enzymes, substrate binding is often coupled to conformational changes that alter the local environment of the active site to align the reactive groups for efficient catalysis and...

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Detalhes bibliográficos
Main Authors: Fieulaine, Sonia, Boularot, Adrien, Artaud, Isabelle, Desmadril, Michel, Dardel, Frédéric, Meinnel, Thierry, Giglione, Carmela
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101196/
https://ncbi.nlm.nih.gov/pubmed/21629676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001066
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