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Mutations in Three Distinct Loci Cause Resistance to Peptide Deformylase Inhibitors in Bacillus subtilis

Bacillus subtilis mutants with resistance against peptide deformylase inhibitors were isolated. All showed a bypass of the pathway through mutations in three genes required for formylation of Met-tRNA(fMet), fmt, folD, and glyA. glyA corresponds to a yet uncharacterized locus inducing resistance. Th...

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Bibliografski detalji
Glavni autori: Duroc, Yann, Giglione, Carmela, Meinnel, Thierry
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663100/
https://ncbi.nlm.nih.gov/pubmed/19171795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01340-08
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