Pharmacokinetics in Animals and Humans of a First-in-Class Peptide Deformylase Inhibitor

BB-83698, a potent and selective inhibitor of peptide deformylase, was the first compound of this novel antibacterial class to progress to clinical trials. Single- and/or multiple-dose studies with doses ranging from 10 to 50 mg of BB-83698/kg of body weight were done with mice, rats, and dogs. Intr...

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Bibliographic Details
Main Authors: Ramanathan-Girish, Sandhya, McColm, Juliet, Clements, John M., Taupin, Phil, Barrowcliffe, Sue, Hevizi, John, Safrin, Sharon, Moore, Clive, Patou, Gary, Moser, Heinz, Gadd, Alison, Hoch, Ute, Jiang, Vernon, Lofland, Denene, Johnson, Kirk W.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC529202/
https://ncbi.nlm.nih.gov/pubmed/15561864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4835-4842.2004
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