Pharmacokinetics in Animals and Humans of a First-in-Class Peptide Deformylase Inhibitor

BB-83698, a potent and selective inhibitor of peptide deformylase, was the first compound of this novel antibacterial class to progress to clinical trials. Single- and/or multiple-dose studies with doses ranging from 10 to 50 mg of BB-83698/kg of body weight were done with mice, rats, and dogs. Intr...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Ramanathan-Girish, Sandhya, McColm, Juliet, Clements, John M., Taupin, Phil, Barrowcliffe, Sue, Hevizi, John, Safrin, Sharon, Moore, Clive, Patou, Gary, Moser, Heinz, Gadd, Alison, Hoch, Ute, Jiang, Vernon, Lofland, Denene, Johnson, Kirk W.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2004
Soggetti:	Mechanisms of Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC529202/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15561864/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.12.4835-4842.2004
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