Dynamic Assessment of Mitoxantrone Resistance and Modulation of Multidrug Resistance by Valspodar (PSC833) in Multidrug Resistance Human Cancer Cells

P-glycoprotein (Pgp), a member of the ATP-binding cassette transporter family, is one of the major causes for multidrug resistance (MDR). We report using confocal microscopy to study the roles of Pgp in mediating the efflux of the anticancer agent mitoxantrone and the reversal of MDR by the specific...

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Detalhes bibliográficos
Main Authors: Shen, Fei, Bailey, Barbara J., Chu, Shaoyou, Bence, Aimee K., Xue, Xinjian, Erickson, Priscilla, Safa, Ahmad R., Beck, William T., Erickson, Leonard C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Chemotherapy, Antibiotics, and Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713081/
https://ncbi.nlm.nih.gov/pubmed/19423841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.153551
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