Phase I Study of Valspodar (PSC-833) with Mitoxantrone and Etoposide in Refractory and Relapsed Pediatric Acute Leukemia: A Report from the Children’s Oncology Group

BACKGROUND: Valspodar, a non-immunosuppressive analog of cylosporine, is a potent P-glycoprotein (MDR1) inhibitor. As MDR1-mediated efflux of chemotherapeutic agents from leukemic blasts may contribute to drug resistance, a phase 1 study of valspodar combined with mitoxantrone and etoposide in pedia...

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Detalhes bibliográficos
Main Authors: O’Brien, Maureen M., Lacayo, Norman J., Lum, Bert L., Kshirsagar, Smita, Buck, Steven, Ravindranath, Yaddanapudi, Bernstein, Mark, Weinstein, Howard, Chang, Myron N., Arceci, Robert J., Sikic, Branimir I., Dahl, Gary V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838930/
https://ncbi.nlm.nih.gov/pubmed/20209646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22366
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