Phase I Study of Valspodar (PSC-833) with Mitoxantrone and Etoposide in Refractory and Relapsed Pediatric Acute Leukemia: A Report from the Children’s Oncology Group

BACKGROUND: Valspodar, a non-immunosuppressive analog of cylosporine, is a potent P-glycoprotein (MDR1) inhibitor. As MDR1-mediated efflux of chemotherapeutic agents from leukemic blasts may contribute to drug resistance, a phase 1 study of valspodar combined with mitoxantrone and etoposide in pedia...

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Autors principals: O’Brien, Maureen M., Lacayo, Norman J., Lum, Bert L., Kshirsagar, Smita, Buck, Steven, Ravindranath, Yaddanapudi, Bernstein, Mark, Weinstein, Howard, Chang, Myron N., Arceci, Robert J., Sikic, Branimir I., Dahl, Gary V.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838930/
https://ncbi.nlm.nih.gov/pubmed/20209646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22366
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