Intracellular Levels of Two Cyclosporin Derivatives Valspodar (PSC 833) and Cyclosporin A Closely Associated with Multidrug Resistance‐modulating Activity in Sublines of Human Colorectal Adenocarcinoma HCT‐15

P‐Glycoprotein, which mediates multidrug resistance (MDR) in cancer chemotherapy, is a principal target of Cyclosporin A and [3′‐keto‐Bmt(1)]‐[Val(2)]‐cyclosporin (valspodar; PSC 833). To clarify mechanisms contributing to the different MDR‐modulating activities of valspodar and Cyclosporin A, we in...

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Bibliografiset tiedot
Julkaisussa:Jpn J Cancer Res
Päätekijät: Uchiyama‐Kokubu, Noriko, Watanabe, Toru, Cohen, Dalia
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Blackwell Publishing Ltd 2001
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926616/
https://ncbi.nlm.nih.gov/pubmed/11676863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2001.tb01067.x
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