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Intracellular Levels of Two Cyclosporin Derivatives Valspodar (PSC 833) and Cyclosporin A Closely Associated with Multidrug Resistance‐modulating Activity in Sublines of Human Colorectal Adenocarcinoma HCT‐15
P‐Glycoprotein, which mediates multidrug resistance (MDR) in cancer chemotherapy, is a principal target of Cyclosporin A and [3′‐keto‐Bmt(1)]‐[Val(2)]‐cyclosporin (valspodar; PSC 833). To clarify mechanisms contributing to the different MDR‐modulating activities of valspodar and Cyclosporin A, we in...
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| Publicado no: | Jpn J Cancer Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5926616/ https://ncbi.nlm.nih.gov/pubmed/11676863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2001.tb01067.x |
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