Phase I Study of Intravenous PSC‐833 and Doxorubicin: Reversal of Multidrug Resistance

PSC‐833 reverses multidrug resistance by P‐glycoprotein at concentrations <1000 ng/ml. A phase I study of PSC‐833 and doxorubicin was conducted to determine the maximum tolerated dose and to investigate pharmacokinetics. PSC‐833 was intravenously infused as a 2‐h loading dose (LD) and a subsequen...

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Publicat a:Jpn J Cancer Res
Autors principals: Minami, Hironobu, Ohtsu, Tomoko, Fujii, Hirofumi, Igarashi, Tadahiko, Itoh, Kuniaki, Uchiyama‐Kokubu, Noriko, Aizawa, Tetsushi, Watanabe, Torn, Uda, Yoshinori, Tanigawara, Yusuke, Sasaki, Yasutsuna
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2001
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926698/
https://ncbi.nlm.nih.gov/pubmed/11223552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2001.tb01085.x
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