A Limited Sampling Model for Estimating Pharmacokinetics of CPT‐11 and Its Metabolite SN‐38

The objective of this study was to develop a limited sampling model (LSM) to estimate the area under the curve (AUC) of 7‐ethyl‐10‐[4‐(1‐piperidino)‐1‐piperidino]carbonyloxycamptothecin (CPT‐11) and that of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38) as predictive pharmacokinetic variables for leukopenia...

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Enregistré dans:
Détails bibliographiques
Publié dans:Jpn J Cancer Res
Auteurs principaux: Sasaki, Yasutsuna, Mizuno, Shoichi, Fujii, Hirofumi, Ohtsu, Tomoko, Wakita, Hisashi, Igarashi, Tadahiko, Itoh, Kuniaki, Sekine, Ikuo, Miyata, Yoshinori, Saijo, Nagahiro
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 1995
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920588/
https://ncbi.nlm.nih.gov/pubmed/7737903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1995.tb02996.x
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