A Pharmacokinetic and Pharmacodynamic Analysis of CPT‐11 and Its Active Metabolite SN‐38

In the present study, an attempt was made to determine the precise pharmacokinetics of 7‐ethyl‐10‐[4‐(1‐piperidino)‐1‐piperidino]carbonyloxycamptothecin (CPT‐11) and its active metabolite, 7‐ethyl‐10‐hydroxycamptothecin (SN‐38). The relationship between pharmacokinetic parameters and pharmacodynamic...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Sasaki, Yasutsuna, Hakusui, Hideo, Mizuno, Shoichi, Morita, Masashige, Miya, Toshimichi, Eguchi, Kenji, Shinkai, Tetsu, Tamura, Tomohide, Ohe, Yuichiro, Saijo, Nagahiro
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1995
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920579/
https://ncbi.nlm.nih.gov/pubmed/7737901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1995.tb02994.x
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