Pharmacological Correlation between Total Drug Concentration and Lactones of CPT‐11 and SN‐38 in Patients Treated with CPT‐11

The pharmacokinetics of 7‐ethyl‐10‐[4‐(1‐piperidino)‐1‐piperidino]carbonyloxycamptothecin (CPT‐11) and its active metabolite, 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), were examined to establish the pharmacokinetic variability of the active lactones of CPT‐11 and SN‐38 in comparison with that of the t...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Sasaki, Yasutsuna, Yoshida, Yasushi, Sudoh, Kenichi, Hakusui, Hideo, Fujii, Hirofumi, Ohtsu, Tomoko, Wakita, Hisashi, Igarashi, Tadahiko, Itoh, Kuniaki
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1995
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920577/
https://ncbi.nlm.nih.gov/pubmed/7737902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1995.tb02995.x
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