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Urea Impedes the Hydrophobic Collapse of Partially Unfolded Proteins

Proteins are denatured in aqueous urea solution. The nature of the molecular driving forces has received substantial attention in the past, whereas the question how urea acts at different phases of unfolding is not yet well understood at the atomic level. In particular, it is unclear whether urea ac...

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Detalhes bibliográficos
Main Authors: Stumpe, Martin C., Grubmüller, Helmut
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711416/
https://ncbi.nlm.nih.gov/pubmed/19413980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.01.051
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