Phase II Trial of Gliadel® plus O(6)-Benzylguanine (O(6)-BG) in Adults with Recurrent Glioblastoma Multiforme

PURPOSE: This phase II trial was designed to: define the efficacy of Gliadel® wafers in combination with an infusion of O(6)-BG that suppresses tumor O(6)-alkylguanine-DNA alkyltransferase (AGT) levels in patients with recurrent GBM for 5 days; and evaluate the safety of this combination therapy. PA...

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Detalhes bibliográficos
Main Authors: Quinn, Jennifer A., Jiang, Sara Xiaoyin, Carter, James, Reardon, David A., Desjardins, Annick, Vredenburgh, James J., Rich, Jeremy N., Gururangan, Sridharan, Friedman, Allan H., Bigner, Darell D., Sampson, John H., McLendon, Roger E., Herndon, James E., Threatt, Stevie, Friedman, Henry S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710963/
https://ncbi.nlm.nih.gov/pubmed/19188181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-2130
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