Phase II Trial of Temozolomide Plus O(6)-Benzylguanine in Adults With Recurrent, Temozolomide-Resistant Malignant Glioma

PURPOSE: This phase II trial was designed to define the role of O(6)-benzylguanine (O(6)-BG) in restoring temozolomide sensitivity in patients with recurrent or progressive, temozolomide-resistant malignant glioma and to evaluate the safety of administering O(6)-BG in combination with temozolomide....

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Detalhes bibliográficos
Main Authors: Quinn, Jennifer A., Jiang, Sara Xiaoyin, Reardon, David A., Desjardins, Annick, Vredenburgh, James J., Rich, Jeremy N., Gururangan, Sridharan, Friedman, Allan H., Bigner, Darell D., Sampson, John H., McLendon, Roger E., Herndon, James E., Walker, Amy, Friedman, Henry S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2009
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667825/
https://ncbi.nlm.nih.gov/pubmed/19204199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.18.8417
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