Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon based somatic mutagenesis screen

Retroviral and transposon-based mutagenesis screens in mice have been useful for identifying candidate cancer genes for some tumor types. However, many of the organs that exhibit the highest cancer rates in humans, including the prostate, have not previously been amenable to these approaches. This s...

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Autori principali: Rahrmann, Eric P., Collier, Lara S., Knutson, Todd P., Doyal, Meghan E., Kuslak, Sheri L., Green, Laura E., Malinowski, Rita L., Roethe, Laura, Akagi, Keiko, Waknitz, Michelle, Huang, Wei, Largaespada, David A., Marker, Paul C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710962/
https://ncbi.nlm.nih.gov/pubmed/19401450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3901
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