Essential role for DNA-PKcs in DNA double strand break repair and apoptosis in ATM deficient lymphocytes

The DNA double strand break (DSB) repair protein DNA-PKcs and the signal transducer ATM are both activated by DNA breaks and phosphorylate similar substrates in vitro, yet appear to have distinct functions in vivo. Here we show that ATM and DNA-PKcs have overlapping functions in lymphocytes. Ablatio...

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Autori principali: Callén, Elsa, Jankovic, Mila, Wong, Nancy, Zha, Shan, Chen, Hua-Tang, Difilippantonio, Simone, Di Virgilio, Michela, Heidkamp, Gordon, Alt, Frederick W., Nussenzweig, André, Nussenzweig, Michel
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709792/
https://ncbi.nlm.nih.gov/pubmed/19450527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.04.025
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