Essential role for DNA-PKcs in DNA double strand break repair and apoptosis in ATM deficient lymphocytes

The DNA double strand break (DSB) repair protein DNA-PKcs and the signal transducer ATM are both activated by DNA breaks and phosphorylate similar substrates in vitro, yet appear to have distinct functions in vivo. Here we show that ATM and DNA-PKcs have overlapping functions in lymphocytes. Ablatio...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Callén, Elsa, Jankovic, Mila, Wong, Nancy, Zha, Shan, Chen, Hua-Tang, Difilippantonio, Simone, Di Virgilio, Michela, Heidkamp, Gordon, Alt, Frederick W., Nussenzweig, André, Nussenzweig, Michel
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709792/
https://ncbi.nlm.nih.gov/pubmed/19450527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.04.025
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires