Functional specificity of a Hox protein mediated by the recognition of minor groove structure

The recognition of specific DNA binding sites by transcription factors is a critical yet poorly understood step in the control of gene expression. Members of the Hox family of transcription factors bind DNA by making nearly identical major groove contacts via the recognition helices of their homeodo...

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Autores principales: Joshi, Rohit, Passner, Jonathan M., Rohs, Remo, Jain, Rinku, Sosinsky, Alona, Crickmore, Michael A., Jacob, Vinitha, Aggarwal, Aneel K., Honig, Barry, Mann, Richard S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709780/
https://ncbi.nlm.nih.gov/pubmed/17981120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.09.024
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