Prostaglandin E(2) Stimulates the Production of Amyloid-β Peptides through Internalization of the EP(4) Receptor

Amyloid-β (Aβ) peptides, generated by the proteolysis of β-amyloid precursor protein by β- and γ-secretases, play an important role in the pathogenesis of Alzheimer disease. Inflammation is also important. We recently reported that prostaglandin E(2) (PGE(2)), a strong inducer of inflammation, stimu...

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Hlavní autoři: Hoshino, Tatsuya, Namba, Takushi, Takehara, Masaya, Nakaya, Tadashi, Sugimoto, Yukihiko, Araki, Wataru, Narumiya, Shuh, Suzuki, Toshiharu, Mizushima, Tohru
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709369/
https://ncbi.nlm.nih.gov/pubmed/19407341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.003269
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