Endoplasmic reticulum chaperones inhibit the production of amyloid-β peptides

Aβ (amyloid-β peptides) generated by proteolysis of APP (β-amyloid precursor protein), play an important role in the pathogenesis of AD (Alzheimer's disease). ER (endoplasmic reticulum) chaperones, such as GRP78 (glucose-regulated protein 78), make a major contribution to protein quality contro...

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Detalhes bibliográficos
Main Authors: Hoshino, Tatsuya, Nakaya, Tadashi, Araki, Wataru, Suzuki, Keitarou, Suzuki, Toshiharu, Mizushima, Tohru
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1863563/
https://ncbi.nlm.nih.gov/pubmed/17132139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061318
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