Neuroserpin Polymers Activate NF-κB by a Calcium Signaling Pathway That Is Independent of the Unfolded Protein Response

The autosomal dominant dementia familial encephalopathy with neuroserpin inclusion bodies is characterized by the accumulation of ordered polymers of mutant neuroserpin within the endoplasmic reticulum of neurones. We show here that intracellular neuroserpin polymers activate NF-κB by a pathway that...

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Detalhes bibliográficos
Principais autores: Davies, Mark J., Miranda, Elena, Roussel, Benoit D., Kaufman, Randal J., Marciniak, Stefan J., Lomas, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709363/
https://ncbi.nlm.nih.gov/pubmed/19423713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.010744
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