Characterization, chemical optimization and anti-tumour activity of a tubulin poison identified by a p53-based phenotypic screen

A robust p53 cell-based assay that exploits p53’s function as a transcription factor was used to screen a small molecule library and identify bioactive small molecules with potential antitumor activity. Unexpectedly, the majority of the highest ranking hit compounds from this screen arrest cells in...

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Autors principals: Staples, Oliver D., Hollick, Jonathan J., Campbell, Johanna, Higgins, Maureen, McCarthy, Anna R., Appleyard, Virginia, Murray, Karen E., Baker, Lee, Thompson, Alastair, Ronseaux, Sebastien, Slawin, Alexandra M.Z., Lane, David P., Westwood, Nicholas J., Lain, Sonia
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709220/
https://ncbi.nlm.nih.gov/pubmed/18971638
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