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Identification of a consensus motif in substrates bound by a Type I Hsp40

Protein aggregation is a hallmark of a large and diverse number of conformational diseases. Molecular chaperones of the Hsp40 family (Escherichia coli DnaJ homologs) recognize misfolded disease proteins and suppress the accumulation of toxic protein species. Type I Hsp40s are very potent at suppress...

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Main Authors: Kota, Pradeep, Summers, Daniel W., Ren, Hong-Yu, Cyr, Douglas M., Dokholyan, Nikolay V.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708756/
https://ncbi.nlm.nih.gov/pubmed/19549854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900746106
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