Synergistic drug combinations improve therapeutic selectivity

Prevailing drug discovery approaches focus on compounds with molecular selectivity, inhibiting disease-relevant targets over others in vitro. However in vivo, many such agents are not therapeutically selective, either because of undesirable activity at effective doses or because the biological syste...

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Autori principali: Lehàr, Joseph, Krueger, Andrew S., Avery, William, Heilbut, Adrian M., Johansen, Lisa M., Price, E. Roydon, Rickles, Richard J., Short, Glenn F., Staunton, Jane E., Jin, Xiaowei, Lee, Margaret S., Zimmermann, Grant R., Borisy, Alexis A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708317/
https://ncbi.nlm.nih.gov/pubmed/19581876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1549
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