Synergistic drug combinations improve therapeutic selectivity

Prevailing drug discovery approaches focus on compounds with molecular selectivity, inhibiting disease-relevant targets over others in vitro. However in vivo, many such agents are not therapeutically selective, either because of undesirable activity at effective doses or because the biological syste...

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Detalhes bibliográficos
Main Authors: Lehàr, Joseph, Krueger, Andrew S., Avery, William, Heilbut, Adrian M., Johansen, Lisa M., Price, E. Roydon, Rickles, Richard J., Short, Glenn F., Staunton, Jane E., Jin, Xiaowei, Lee, Margaret S., Zimmermann, Grant R., Borisy, Alexis A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708317/
https://ncbi.nlm.nih.gov/pubmed/19581876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1549
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