Synergistic drug combinations improve therapeutic selectivity

Prevailing drug discovery approaches focus on compounds with molecular selectivity, inhibiting disease-relevant targets over others in vitro. However in vivo, many such agents are not therapeutically selective, either because of undesirable activity at effective doses or because the biological syste...

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Bibliographic Details
Main Authors: Lehàr, Joseph, Krueger, Andrew S., Avery, William, Heilbut, Adrian M., Johansen, Lisa M., Price, E. Roydon, Rickles, Richard J., Short, Glenn F., Staunton, Jane E., Jin, Xiaowei, Lee, Margaret S., Zimmermann, Grant R., Borisy, Alexis A.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708317/
https://ncbi.nlm.nih.gov/pubmed/19581876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1549
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