Selective amplification of glucocorticoid anti-inflammatory activity through synergistic multi-target action of a combination drug

INTRODUCTION: Glucocorticoids are a mainstay of anti-inflammatory therapy, but significant adverse effects ultimately limit their utility. Previous efforts to design glucocorticoid structures with an increased therapeutic window have focused on dissociating anti-inflammatory transcriptional repressi...

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Библиографические подробности
Главные авторы: Zimmermann, Grant R, Avery, William, Finelli, Alyce L, Farwell, Melissa, Fraser, Christopher C, Borisy, Alexis A
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2009
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688244/
https://ncbi.nlm.nih.gov/pubmed/19171052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2602
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