Chemical combination effects predict connectivity in biological systems

Efforts to construct therapeutically useful models of biological systems require large and diverse sets of data on functional connections between their components. Here we show that cellular responses to combinations of chemicals reveal how their biological targets are connected. Simulations of path...

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Hlavní autoři: Lehár, Joseph, Zimmermann, Grant R, Krueger, Andrew S, Molnar, Raymond A, Ledell, Jebediah T, Heilbut, Adrian M, Short, Glenn F, Giusti, Leanne C, Nolan, Garry P, Magid, Omar A, Lee, Margaret S, Borisy, Alexis A, Stockwell, Brent R, Keith, Curtis T
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828746/
https://ncbi.nlm.nih.gov/pubmed/17332758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb4100116
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