The Selective α7 Agonist GTS-21 Attenuates Cytokine Production in Human Whole Blood and Human Monocytes Activated by Ligands for TLR2, TLR3, TLR4, TLR9, and RAGE

The cholinergic antiinflammatory pathway modulates inflammatory cytokine production through a mechanism dependent on the vagus nerve and the α7 subunit of the nicotinic acetylcholine receptor. GTS-21 [3-(2,4-dimethoxybenzylidene) anabaseine], a selective α7 agonist, inhibits inflammatory cytokine pr...

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Detalhes bibliográficos
Main Authors: Rosas-Ballina, Mauricio, Goldstein, Richard S, Gallowitsch-Puerta, Margot, Yang, Lihong, Valdés-Ferrer, Sergio Iván, Patel, Nirav B, Chavan, Sangeeta, Al-Abed, Yousef, Yang, Huan, Tracey, Kevin J
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707516/
https://ncbi.nlm.nih.gov/pubmed/19593403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2009.00039
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