Modulation of TNF Release by Choline Requires α7 Subunit Nicotinic Acetylcholine Receptor-Mediated Signaling

The α7 subunit-containing nicotinic acetylcholine receptor (α7nAChR) is an essential component in the vagus nerve-based cholinergic anti-inflammatory pathway that regulates the levels of TNF, high mobility group box 1 (HMGB1), and other cytokines during inflammation. Choline is an essential nutrient...

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Main Authors: Parrish, William R, Rosas-Ballina, Mauricio, Gallowitsch-Puerta, Margot, Ochani, Mahendar, Ochani, Kanta, Yang, Li-Hong, Hudson, LaQueta, Lin, Xinchun, Patel, Nirav, Johnson, Sarah M, Chavan, Sangeeta, Goldstein, Richard S, Czura, Christopher J, Miller, Edmund J, Al-Abed, Yousef, Tracey, Kevin J, Pavlov, Valentin A
Format: Artigo
Jezik:Inglês
Izdano: ScholarOne 2008
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435495/
https://ncbi.nlm.nih.gov/pubmed/18584048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/2008-00079.Parrish
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