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Structural Model for Dihydropyridine Binding to L-type Calcium Channels

1,4-Dihydropyridines (DHPs) constitute a major class of ligands for L-type Ca(2+) channels (LTCC). The DHPs have a boat-like, six-membered ring with an NH group at the stern, an aromatic moiety at the bow, and substituents at the port and starboard sides. Various DHPs exhibit antagonistic or agonist...

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Autors principals: Tikhonov, Denis B., Zhorov, Boris S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707233/
https://ncbi.nlm.nih.gov/pubmed/19416978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.011296
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