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Structural Model for Phenylalkylamine Binding to L-type Calcium Channels
Phenylalkylamines (PAAs), a major class of L-type calcium channel (LTCC) blockers, have two aromatic rings connected by a flexible chain with a nitrile substituent. Structural aspects of ligand-channel interactions remain unclear. We have built a KvAP-based model of LTCC and used Monte Carlo energy...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2788883/ https://ncbi.nlm.nih.gov/pubmed/19700404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.027326 |
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