Insulin Receptor Dysfunction Impairs Cellular Clearance of Neurotoxic Oligomeric Aβ

Accumulation of amyloid β (Aβ) oligomers in the brain is toxic to synapses and may play an important role in memory loss in Alzheimer disease. However, how these toxins are built up in the brain is not understood. In this study we investigate whether impairments of insulin and insulin-like growth fa...

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Bibliografiske detaljer
Main Authors: Zhao, Wei-Qin, Lacor, Pascale N., Chen, Hui, Lambert, Mary P., Quon, Michael J., Krafft, Grant A., Klein, William L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707198/
https://ncbi.nlm.nih.gov/pubmed/19406747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.011015
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