Crystal Structure of a “Nonfoldable” Insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY

Protein evolution is constrained by folding efficiency (“foldability”) and the implicit threat of toxic misfolding. A model is provided by proinsulin, whose misfolding is associated with β-cell dysfunction and diabetes mellitus. An insulin analogue containing a subtle core substitution (Leu(A16) → V...

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Detalhes bibliográficos
Main Authors: Liu, Ming, Wan, Zhu-li, Chu, Ying-Chi, Aladdin, Hassan, Klaproth, Birgit, Choquette, Meredith, Hua, Qing-xin, Mackin, Robert B., Rao, J. Sunil, De Meyts, Pierre, Katsoyannis, Panayotis G., Arvan, Peter, Weiss, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787385/
https://ncbi.nlm.nih.gov/pubmed/19850922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.046888
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