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Quantifying and correcting for the winner's curse in genetic association studies

Genetic association studies are a powerful tool to detect genetic variants that predispose to human disease. Once an associated variant is identified, investigators are also interested in estimating the effect of the identified variant on disease risk. Estimates of the genetic effect based on new as...

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Autors principals: Xiao, Rui, Boehnke, Michael
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706290/
https://ncbi.nlm.nih.gov/pubmed/19140131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.20398
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