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Quantifying and correcting for the winner's curse in genetic association studies

Genetic association studies are a powerful tool to detect genetic variants that predispose to human disease. Once an associated variant is identified, investigators are also interested in estimating the effect of the identified variant on disease risk. Estimates of the genetic effect based on new as...

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Bibliographic Details
Main Authors: Xiao, Rui, Boehnke, Michael
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706290/
https://ncbi.nlm.nih.gov/pubmed/19140131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.20398
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