Overexpression of MYC causes p53-dependent G(2) arrest of normal fibroblasts

Overexpression of the proto-oncogene MYC has been implicated in the genesis of diverse human cancers. One explanation for the role of MYC in tumorigenesis has been that this gene might drive cells inappropriately through the division cycle, leading to the relentless proliferation characteristic of t...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Felsher, Dean W., Zetterberg, Anders, Zhu, Jiyue, Tlsty, Thea, Bishop, J. Michael
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2000
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27061/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10962037/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.190327097
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